ʻO ka papa lāʻau lapaʻau maʻemaʻe kiʻekiʻe 1421373-66-1 Mesylate-AZD9291 no ka mālama ʻana i ka maʻi maʻi.
| Huahanainoa | AZD-9291 mesylate |
| Nā huaʻōlelo like | N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 2-propenamide methanesulfonate (1:1) |
| CAS No. | 1421373-66-1 |
| Ka nana aku | Keʻokeʻo a ʻulaʻula melemele paʻa paʻa |
| ʻĀpana Molekala | C28H33N7O2.CH4O3S |
| Kaumaha Molekala | 595.71 |
| Hoʻohana | Lapaʻau Lapaʻau a i ʻole ke kumu noiʻi |
| Hoʻopili | E like me kāu noi |
| Waihona | E mālama i loko o nā pahu paʻa a me ka māmā ma kahi anuanu |
| AZD-9291 mesylateCAS:1421373-66-1 | ||
| Items | Standards | Rnā hopena |
| Ka nana aku | Keʻokeʻo a ʻulaʻula melemele paʻa paʻa | ʻO ka pauka paʻa melemele māmā |
| Iʻike ʻike | Na IR | Hoʻokō |
| Na HPLC | Hoʻokō | |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka Dimethylsulfoxide, hiki ke hoʻoheheʻe ʻia i ka Ethanol a me ka Acetonitrile, me ka hoʻoheheʻe wai pili i ka pH. | Hoʻokō |
| Waiwai(KF) | ≤ 1.00% | 0.42% |
| Koena ma ka Ignition | ≤ 0.10% | 0.05% |
| HeavyMetal | ≤ 20ppm | Hoʻokō |
| Mesylate | 15.20%~18.20% | 15.90% |
| Nā mea hoʻoheheʻe koena | Acetonitrile: ≤410ppm | ND |
| Acetone: ≤5000ppm | ND | |
| Tetrahydrofuran: ≤720ppm | ND | |
| RhauʻoliSnā mea lāʻau | ʻO ka haumia hoʻokahi kiʻekiʻe loa: ≤0.20% | 0.17% |
| Huina haumia: ≤1.00% | 0.25% | |
| Nui ʻāpana | D90: ≤100μm | 57.97% |
| Aʻōlelo (HPLC kumu ma ka maloʻo) | 98.00%~102.00% | 99.80% |
| Kūlana Kūlana | Kūloko o ka hale | |
ʻIkepili Hui
√ Ka ʻike piha o ka papa hoʻokele ma ka hale hana a me nā mea ʻenehana akamai; √ ʻO ka maikaʻi ka mea i manaʻo nui ʻia, ʻōnaehana QC koʻikoʻi; √ 11 makahiki i ʻike i ka lawe ʻana i nā hui kūʻai; √ Keʻena hana R&D kūʻokoʻa; √ ʻElua mau papa hana GMP lōʻihi i pūlima ʻia; √ Nā waiwai waiwai o nā hale hana palaualelo no ka papahana maʻamau; √ Kiʻekiʻe Efficiency hui hana me ke ala mau.
E kākau i kāu leka ma aneʻi a hoʻouna mai iā mākou
